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Exotics-Shop research chemicals refer to a category of compounds ranging from Tryptamines to Lysergamides. Research chemicals are not for human consumption. When asking what ALD-52 is, please keep in mind that this article is for educational purposes only. Outside of institutional research, people conduct ALD-52 research as a hobby. We can make a comparison to star gazing. Why would someone spend time star gazing? You can’t visit the stars. The likelihood of discovering a new planet or something else is virtually nil. And recording changes in the night sky doesn’t have any bearing on your everyday reality (unless you’re really into astrology). But for many people, busting out the telescope and tracking the night sky is a fun, passionate hobby. It gives them a sense of place and purpose. They may like doing the math that’s involved with amateur astronomy. For example, an amateur astronomer may use spectroscopy to determine the contents of a particular star. Now, they could Google this information, but where’s the fun in that? In the same way, research chemicals give us insight into the molecular structure of interesting compounds. Just as an amateur astronomer doesn’t plan to visit or communicate with these distant stars, researchers don’t consume their research chemicals.

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What is Lysergamides?

 Lysergamides are amides of lysergic acid. They can also technically be referred to as complex Tryptamines, similar to Ibogaine.

Lysergamides have both phenethylamine and tryptamine groups embedded within their structure, as well as a carboxamide group attached to carbon number eight. 

The pharmacological effects of lysergamides are assumed to come from their efficacy as a partial agonist of the 5-HT2A receptor, though they are known to have an affinity to a much greater variety of receptors than other psychedelic compounds.

The (surprisingly dark) History of Lysergamides

The first discovered lysergamides came from a fungus called ergot that can be found on rye and other grains. This fungus contains both lysergic acid and a precursor of LSD, ergotamine. Ingestion of grains containing ergot led to the condition called “ergotism”, which wreaked havoc around the turn of the first millennium. The worst incidence of this was one night in the year 944AD in France, where much of the population were unknowingly consuming rye bread that had become infected with ergot. Two hours later, people flooded the streets, assumed to be mad. Over 40,000 people died over the course of a few days in what became known as the “Ergot epidemic”. Interestingly, the term “werewolf” was first coined to describe people who were afflicted by ergotism.

It wasn’t until 1938 that Albert Hoffman first developed lysergic acid diethylamide or LSD while working with this same fungus and the psychedelics revolution of the 20th century began. 

Since then, a vast array of LSD analogues have been discovered and synthesised; some of these by Hoffman himself during the 60s (ALD-52 for example) and many in just the last 10 years by the Dutch based laboratory Lizard Labs (these include 1P-LSD, 1cP-LSD, 1B-LSD, 1V-LSD and 1D-LSD).

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What  is Tryptamines?

Tryptamines are a group of organic compounds that are based on a tryptamine core structure. 

The class is composed of all derivative compounds that can be formed by substituting one or more hydrogen atoms in the core structure with other substituents. Naturally occurring tryptamines are found in many plants and animals. These are formed from the decarboxylation of the essential amino acid tryptophan.

The tryptamine class is composed of a huge variety of compounds, many of which are fundamentally important to human biology like serotonin (the “happy hormone”) and melatonin (the “sleep hormone”). 

Some psychoactive tryptamines can be found in nature, like DMT (dimethyltryptamine) and 5-MeO-DMT (which both can be found in the human body), while many others have been discovered through chemical synthesis in recent years.

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Phenethylamines are a large group of organic compounds based upon the phenethylamine structure. They encompass an incredibly wide variety of psychoactive substances as well as hormones found naturally in the body. The pharmacological effects of substituted phenethylamines also vary substantially, so one should not expect a similar subjective experience just because two compounds happen to fall within this same chemical class.

Some examples of different classes that share the phenethylamine base structure are central nervous stimulants (for example, amphetamines such as 3-FEA), hallucinogens (such as 2C-B-FLY and methallylescaline), entactogens (like 5-MAPB), appetite suppressants and antidepressants. Phenethylamines also include numerous endogenous hormones, such as dopamine (the “reward system” hormone), norepinephrine (also known as adrenaline – the “stress” hormone), tyramine and others.

As you can see, the class “substituted phenethylamines” includes a whole host of different chemicals and hormones, some producing substantially different pharmacological effects from one another. The reason for this is because, while they share the same base structure, phenethylamines do not have a single common biological target or method of action; as opposed to – for example – the lysergamide chemical class, of which all derivatives target the 5-HT receptors. 

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